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TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease.
Lee JH, Lee JM, Ramos EM, Gillis T, Mysore JS, Kishikawa S, Hadzi T, Hendricks AE, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Gellera C, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Landwehrmeyer GB; Registry Study of the European Huntington's Disease Network; Shoulson I; Huntington Study Group COHORT project; Myers RH, MacDonald ME, Gusella JF. Lee JH, et al. Biochem Biophys Res Commun. 2012 Aug 3;424(3):404-8. doi: 10.1016/j.bbrc.2012.06.120. Epub 2012 Jul 3. Biochem Biophys Res Commun. 2012. PMID: 22771793 Free PMC article.
Prior to investing in detailed studies of the functional impact of this polymorphism, we sought to confirm its effect on age at onset in a much larger dataset than in previous investigations. We genotyped the HD CAG repeat and the GRIK2 TAA repeat in DNA samples from 2,911 …
Prior to investing in detailed studies of the functional impact of this polymorphism, we sought to confirm its effect on age at onset in a m …
Genetic analysis of the GRIK2 modifier effect in Huntington's disease.
Zeng W, Gillis T, Hakky M, Djoussé L, Myers RH, MacDonald ME, Gusella JF. Zeng W, et al. BMC Neurosci. 2006 Sep 7;7:62. doi: 10.1186/1471-2202-7-62. BMC Neurosci. 2006. PMID: 16959037 Free PMC article.
Association of a relatively infrequent 16 TAA allele of a trinucleotide repeat polymorphism in the GRIK2 3'UTR with earlier than expected age at neurological onset has been suggested to reflect linkage disequilibrium with a functional polymorphism in GRIK2 or an adj …
Association of a relatively infrequent 16 TAA allele of a trinucleotide repeat polymorphism in the GRIK2 3'UTR with earlier than expe …
Integrative multilevel exploration of the mechanism by which Er-Zhi-Wan alleviates the Parkinson's disease (PD)-like phenotype in the MPTP-induced PD mouse model.
Pan B, Niu B, He Y, Zhou C, Xia C. Pan B, et al. Biomed Pharmacother. 2023 Sep;165:115021. doi: 10.1016/j.biopha.2023.115021. Epub 2023 Jun 20. Biomed Pharmacother. 2023. PMID: 37348406 Free article.
Furthermore, data from combined multilevel databases and network pharmacology analysis strategies suggested that the neuroprotective activity of EZW in the treatment of PD is mediated by a complicated multicomponent, multitarget network. Genes such as Grm2, Grm5, Drd2, and Gri …
Furthermore, data from combined multilevel databases and network pharmacology analysis strategies suggested that the neuroprotective activit …
Whole-Transcriptome Analysis of Dermal Fibroblasts, Derived from Three Pairs of Monozygotic Twins, Discordant for Parkinson's Disease.
Alieva AK, Rudenok MM, Novosadova EV, Vlasov IN, Arsenyeva EL, Rosinskaya AV, Grivennikov IA, Slominsky PA, Shadrina MI. Alieva AK, et al. J Mol Neurosci. 2020 Feb;70(2):284-293. doi: 10.1007/s12031-019-01452-3. Epub 2019 Dec 10. J Mol Neurosci. 2020. PMID: 31823283 Free PMC article.
The most significant genes, which occupied a central position in this cluster, were PTGS2, SCN9A, and GRIK2. These genes can be considered as potential candidate genes for PD....
The most significant genes, which occupied a central position in this cluster, were PTGS2, SCN9A, and GRIK2. These genes can be consi …
Genetic analysis of candidate genes modifying the age-at-onset in Huntington's disease.
Metzger S, Bauer P, Tomiuk J, Laccone F, Didonato S, Gellera C, Mariotti C, Lange HW, Weirich-Schwaiger H, Wenning GK, Seppi K, Melegh B, Havasi V, Balikó L, Wieczorek S, Zaremba J, Hoffman-Zacharska D, Sulek A, Basak AN, Soydan E, Zidovska J, Kebrdlova V, Pandolfo M, Ribaï P, Kadasi L, Kvasnicova M, Weber BH, Kreuz F, Dose M, Stuhrmann M, Riess O. Metzger S, et al. Hum Genet. 2006 Sep;120(2):285-92. doi: 10.1007/s00439-006-0221-2. Epub 2006 Jul 18. Hum Genet. 2006. PMID: 16847693
To identify genetic modifiers influencing the age at disease onset, we searched for polymorphic markers in the GRIK2, TBP, BDNF, HIP1 and ZDHHC17 genes and analysed seven of them by association studies in 980 independent European HD patients. ...Although some of the factor …
To identify genetic modifiers influencing the age at disease onset, we searched for polymorphic markers in the GRIK2, TBP, BDNF, HIP1 …
Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene.
Valcárcel-Ocete L, Alkorta-Aranburu G, Iriondo M, Fullaondo A, García-Barcina M, Fernández-García JM, Lezcano-García E, Losada-Domingo JM, Ruiz-Ojeda J, Álvarez de Arcaya A, Pérez-Ramos JM, Roos RA, Nielsen JE, Saft C; REGISTRY investigators of the European Huntington's Disease Network; Zubiaga AM, Aguirre A. Valcárcel-Ocete L, et al. PLoS One. 2015 Jul 6;10(7):e0131573. doi: 10.1371/journal.pone.0131573. eCollection 2015. PLoS One. 2015. PMID: 26148071 Free PMC article.
We found suggestive association signals between HD eAO and/or mAO and genetic variation within the E2F2, ATF7IP, GRIN2A, GRIN2B, LINC01559, HIP1 and GRIK2 genes. Among them, the most significant was the association between eAO and rs2742976, mapping to the promoter region …
We found suggestive association signals between HD eAO and/or mAO and genetic variation within the E2F2, ATF7IP, GRIN2A, GRIN2B, LINC01559, …
Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds.
Andresen JM, Gayán J, Cherny SS, Brocklebank D, Alkorta-Aranburu G, Addis EA; US-Venezuela Collaborative Research Group; Cardon LR, Housman DE, Wexler NS. Andresen JM, et al. J Med Genet. 2007 Jan;44(1):44-50. doi: 10.1136/jmg.2006.045153. Epub 2006 Oct 3. J Med Genet. 2007. PMID: 17018562 Free PMC article.
METHODS: Previously tested polymorphisms were analysed in the HD gene itself (HD), the GluR6 kainate glutamate receptor (GRIK2), apolipoprotein E (APOE), the transcriptional coactivator CA150 (TCERG1), the ubiquitin carboxy-terminal hydrolase L1 (UCHL1), p53 (TP53), caspas …
METHODS: Previously tested polymorphisms were analysed in the HD gene itself (HD), the GluR6 kainate glutamate receptor (GRIK2), apol …
A high-resolution genetic map around waltzer on mouse chromosome 10 and identification of a new allele of waltzer.
Bryda EC, Ling H, Flaherty L. Bryda EC, et al. Mamm Genome. 1997 Jan;8(1):1-4. doi: 10.1007/s003359900336. Mamm Genome. 1997. PMID: 9021139
The two linkage maps were consistent, indicating that the lesion in vAlb, which is presumed to be a deletion based on the known action of CHL, is small and has not significantly altered the map at this level of detection. Additionally, three genes (Ros1, Grik2, and Zfa) we …
The two linkage maps were consistent, indicating that the lesion in vAlb, which is presumed to be a deletion based on the known action of CH …